Value Investor
Start free

Alto Neuroscience

ANRO on NYSE. Alto Neuroscience sells companion diagnostics and clinical decision support software to drug developers. Market value $942m.

Watch this stockFree. We tell you when something changes.

Price checks use the past 12 months to June 2026. Quality checks use five annual reports, the latest for the year to December 2025.

Should I look at this?

Not a fit for our list right now

Why it could be worth it

What to watch out for

See Health care stocks that passed both tests

This is not advice. Check the numbers below.

Compare with another stock

Cash yield
past 12 months to June 2026
-7.4%low

For every $100 of what the whole company costs, it produced $-7.41 of spare cash in the past 12 months. A savings account pays about $4.

Price to profit
past 12 months to June 2026
n/a

The filings do not give us enough to work this out.

Return on capital
five annual reports to December 2025
n/a

The filings do not give us enough to work this out.

Quality score: not known. Price score: 0 of 100. Our list needs 70 on quality and 60 on price.

$23.69 a share, 353% above its 1-year low

Over the past year the price has ranged from $5.22 to $37.48.

Pays no dividend

Prices from Tuesday’s close (6 October).

Five years of cash, in billions

-0.0
-0.1
-0.1
2024202512 monthsto Jun '26
Revenue
n/an/a
Operating margin
n/an/a
Debt to equity
0.070.11
Shares outstanding
0.03bn0.04bn

Health checks

  • Free cash flow positive0 of 2 years
  • Accounting looks honest (Beneish)Not enough data
  • Financial strength (Piotroski)Not enough data
  • Profit backed by cash (accruals)Yes
  • Debt0.11× equity
  • Revenue growth, five yearsUnknown
  • Buying back its own sharesNo, 26% more shares since 2024

The quarter to June 2026

How the business did, compared with the same quarter a year earlier.

  • A loss of $28 million, compared with a loss of $18 million a year ago.
  • Over the past 12 months it spent $69 million more cash than it brought in, compared with $57 million a year earlier.
  • 58% more shares than a year ago. Each share owns a bit less of the company.
  • It has $228 million more cash than debt, up from $127 million a year ago.
Profit by quarter
Profit by quarter
Quarter toAmount
September 2024-$17m
December 2024-$15m
March 2025-$15m
June 2025-$18m
September 2025-$14m
December 2025-$16m
March 2026-$26m
June 2026-$28m

From the company's quarterly reports to the SEC.

Dates

Next results (estimated)
n/a
Last annual report (10-K)
16 March 2026
Next quarterly (estimated, 10-Q)
11 November 2026

Who owns it

None of the long-term investors we follow own it. 114 funds in all.

Jun '25
Dec '25
Jun '26

Sold out this quarter

Largest holders overall

From 13F filings for the quarter ended 30 June 2026.

Big holders and activists

9 investors own more than 5%.

  • Perceptive Advisors LLC
    Passive investor
    at least 10.0%0.0 pts
    (filed with 2 related holders)
    Since 30 June 2026
  • Commodore Capital LP
    Passive investor
    at least 9.9%0.0 pts
    (filed with 3 related holders)
    Since 31 March 2026
  • Sirenia Capital Management LP
    Passive investor
    at least 6.2%−1.7 pts
    (filed with 1 related holder)
    Since 30 June 2026
  • BlackRock, Inc.
    Passive investor
    6.0%+3.9 pts
    Since 30 June 2026
  • EcoR1 Capital, LLC
    Passive investor
    at least 5.8%
    (filed with 2 related holders)
    Since 13 July 2026
  • Armistice Capital, LLC
    Passive investor
    at least 4.9%−1.1 pts
    (filed with 1 related holder)
    Since 31 December 2025
  • FMR LLC
    Passive investor
    at least 4.7%
    (filed with 1 related holder)
    Since 31 December 2024
  • Steven A. Cohen
    Passive investor
    at least 3.7%−5.2 pts
    (filed with 5 related holders)
    Since 31 March 2026
  • K2 HealthVentures Equity Trust LLC
    Passive investor
    at least 2.4%−3.2 pts
    (filed with 2 related holders)
    Since 31 December 2025
  • Vestal Point Capital, LP
    Passive investor
    Sold down below 5%
    Since 30 June 2026
  • Sold down below 5%
    Since 31 December 2024

From Schedule 13D and 13G filings: anyone owning more than 5% must file one.

What insiders did

No insider bought shares on the open market in the last 12 months. 1 sold $4m.

  • Smith Nicholas Conrad
    PRESIDENT AND CFO
    Sold
    Date
    30 September 2026
    Shares
    24,056
    Price
    $25.82
    Value
    $621,097
  • Smith Nicholas Conrad
    PRESIDENT AND CFO
    Sold
    Date
    29 September 2026
    Shares
    110,830
    Price
    $26.58
    Value
    $3m

From Form 4 filings: insiders must report trades in their own company's shares within two days.

Warning signs in its filings

Problems the company itself reported to the SEC, in its own words.

None of the warning signs we check for were found.

We look for five warning signs: doubt it can keep going, weak checks on its own accounts, a notice that its past accounts can't be relied on, a change of auditor, and one customer bringing in a big share of sales. We don't check lawsuits, investigations or debt yet.

We checked the auditor's report, internal controls, restatement notices, auditor changes and big customers in the 10-K filed 16 Mar 2026, plus the 10-Q filed 12 Aug 2026 and 8 later 8-Ks.

A 10-K is the yearly report every US company files with the SEC. An 8-K is a short notice of a big event.

What could go wrong

Cheap for a reason is the question the numbers cannot answer.

Whether the price already reflects the risks is what the deep dive is for.

The deep dive

Everything above is arithmetic on public filings. The deep dive reads the last ten years of annual reports, the proxy statements, and the earnings calls, then argues the case the way Buffett, Klarman, and Hohn would, and checks every claim against the source.

  • What the business is worth, as a range, and the margin of safety at today’s price
  • Prices to start buying, buy, and buy hard
  • The three things that would make this a mistake
  • Every number footnoted to the filing it came from
Create a free account to run it

Your first deep dive is free.

What a finished deep dive looks like

Not advice. Numbers on this page come from SEC filings and are updated each night; prices are updated again after the US market closes. The five-year figures are rounded.