Pyxis Oncology

PYXS on Nasdaq. Pyxis Oncology develops cancer drugs for patients with solid tumors. Market value $187m.

Watch this stockFree. We tell you when something changes.

Price checks use the past 12 months to June 2026. Some use the latest annual report instead, as marked. Quality checks use five annual reports, the latest for the year to December 2025.

We can't read total debt from the filing, so debt is left out.

Should I look at this?

Look carefully before going further

Read the warning sign in its own filings

This is not advice. Check the numbers below.

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Cash yield
annual report to December 2025
-37.7%low

For every $100 of what the whole company costs, it produced $-37.70 of spare cash last year. A savings account pays about $4.

Price to profit
past 12 months to June 2026
n/a

The filings do not give us enough to work this out.

Return on capital
five annual reports to December 2025
n/a

The filings do not give us enough to work this out.

Quality score: not known. Price score: 0 of 100. Our list needs 70 on quality and 60 on price.

$2.02 a share, 96% above its 1-year low

Over the past year the price has ranged from $1.03 to $5.55.

Pays no dividend

Prices from Tuesday’s close (6 October).

Five years of cash, in billions

-0.0
-0.1
-0.1
-0.1
-0.1
20212022202320242025
Revenue
n/an/an/a$16m$14m
Operating margin
n/an/an/a-554.1%-609.2%
Debt to equity
n/an/an/an/an/a
Shares outstanding
0.04bn0.04bn0.06bn0.06bn0.08bn

Health checks

  • Free cash flow positive0 of 5 years
  • Accounting checksSkipped: company is not yet profitable
  • DebtUnknown
  • Revenue growth, five yearsUnknown
  • Buying back its own sharesNo, 138% more shares since 2021

The quarter to June 2026

How the business did, compared with the same quarter a year earlier.

  • A loss of $25 million, compared with a loss of $18 million a year ago.
  • 3% more shares than a year ago. Each share owns a bit less of the company.
Sales by quarter
Sales by quarter
Quarter toAmount
September 2024$0
December 2024$0
March 2025Not reported
June 2025$3m
September 2025$0
December 2025$11m
March 2026Not reported
June 2026Not reported
Profit by quarter
Profit by quarter
Quarter toAmount
September 2024-$21m
December 2024-$36m
March 2025-$21m
June 2025-$18m
September 2025-$22m
December 2025-$18m
March 2026-$23m
June 2026-$25m

From the company's quarterly reports to the SEC.

Dates

Next results (estimated)
n/a
Last annual report (10-K)
23 March 2026
Next quarterly (estimated, 10-Q)
12 November 2026

Who owns it

None of the long-term investors we follow own it. 76 funds in all.

Jun '25
Dec '25
Jun '26
Largest holders overall

From 13F filings for the quarter ended 30 June 2026.

Big holders and activists

6 investors own more than 5%.

  • at least 17.5%+5.4 pts
    (filed with 3 related holders)
    Since 1 October 2026
  • Lara Sullivan, M.D.
    Insider or founder
    11.2%+0.9 pts
    Since 31 March 2025
    What they said

    Item 4 of the Schedule 13D is hereby amended and supplemented as follows: The response to Item 3 of this Amendment No. 5 is incorporated by reference herein.

    Read the filing
  • BVF PARTNERS L P/IL
    Passive investor
    at least 10.0%
    (filed with 9 related holders)
    Since 2 July 2026
  • at least 7.7%
    (filed with 2 related holders)
    Since 31 December 2025
  • Coastlands Capital Partners LP
    Passive investor
    at least 5.4%
    (filed with 3 related holders)
    Since 1 October 2026
  • Integrated Core Strategies (US) LLC
    Passive investor
    at least 4.0%
    (filed with 1 related holder)
    Since 31 March 2025
  • BlackRock, Inc.
    Passive investor
    Sold down below 5%
    Since 30 June 2025
  • Sold down below 5%
    Since 30 September 2025
  • Ridgeback Capital Investments LLC
    Passive investor
    Sold down below 5%
    Since 31 December 2024
  • Deep Track Capital, LP
    Passive investor
    Sold down below 5%
    Since 31 December 2024

From Schedule 13D and 13G filings: anyone owning more than 5% must file one.

What insiders did

No insider bought shares on the open market in the last 12 months. 1 sold $107,100, $107,100 of it under preset trading plans.

  • Dupont Jakob
    Director
    Sold
    under a preset trading plan
    Date
    30 June 2026
    Shares
    35,000
    Price
    $3.06
    Value
    $107,100

From Form 4 filings: insiders must report trades in their own company's shares within two days.

Warning signs in its filings

Problems the company itself reported to the SEC, in its own words.

1 serious warning sign in Pyxis Oncology’s filings.

We look for five warning signs: doubt it can keep going, weak checks on its own accounts, a notice that its past accounts can't be relied on, a change of auditor, and one customer bringing in a big share of sales. We don't check lawsuits, investigations or debt yet.

We checked the auditor's report, internal controls, restatement notices, auditor changes and big customers in the 10-K filed 23 Mar 2026, plus the 10-Q filed 13 Aug 2026 and 7 later 8-Ks.

  • Doubt it can keep going

    Serious

    The company or its auditor warned it may not have enough money to last the next year.

    “This condition raises substantial doubt about our ability to continue as a going concern for one year from the date the unaudited condensed consolidated financial statements are issued.”
    Show the full paragraph
    Our future cash flows are dependent on key variables such as our ability to secure additional sources of funding in the form of public or private financing of equity or debt or collaboration agreements or a combination of these. While we remain optimistic to obtain additional funding, the current available cash, cash equivalents and marketable debt securities, even after giving effect to the proceeds from the Private Placement, will not be sufficient to fund our operations over the next 12 months from the date of this Quarterly Report on Form 10-Q. This condition raises substantial doubt about our ability to continue as a going concern for one year from the date the unaudited condensed consolidated financial statements are issued.

    From the 10-Q filed 13 August 2026, Part I, Item 2. Management's Discussion and Analysis. Read it in the filing

A 10-K is the yearly report every US company files with the SEC. An 8-K is a short notice of a big event.

What could go wrong

Cheap for a reason is the question the numbers cannot answer.

Whether the price already reflects the risks is what the deep dive is for.

The deep dive

Everything above is arithmetic on public filings. The deep dive reads the last ten years of annual reports, the proxy statements, and the earnings calls, then argues the case the way Buffett, Klarman, and Hohn would, and checks every claim against the source.

  • What the business is worth, as a range, and the margin of safety at today’s price
  • Prices to start buying, buy, and buy hard
  • The three things that would make this a mistake
  • Every number footnoted to the filing it came from
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What a finished deep dive looks like

Not advice. Numbers on this page come from SEC filings and are updated each night; prices are updated again after the US market closes. The five-year figures are rounded.