Trevi Therapeutics

TRVI on Nasdaq. Trevi Therapeutics develops medicines for patients with chronic cough and itching. Market value $2.0bn.

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Price checks use the past 12 months to June 2026. Quality checks use five annual reports, the latest for the year to December 2025.

We can't read total debt from the filing, so debt is left out.

Should I look at this?

Not a fit for our list right now

See Health care stocks that passed both tests

This is not advice. Check the numbers below.

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Cash yield
past 12 months to June 2026
-2.7%low

For every $100 of what the whole company costs, it produced $-2.70 of spare cash in the past 12 months. A savings account pays about $4.

Price to profit
past 12 months to June 2026
n/a

The filings do not give us enough to work this out.

Return on capital
five annual reports to December 2025
n/a

The filings do not give us enough to work this out.

Quality score: not known. Price score: 0 of 100. Our list needs 70 on quality and 60 on price.

$13.72 a share, 48% above its 1-year low

Over the past year the price has ranged from $9.28 to $20.22.

Pays no dividend

Prices from Monday’s close (5 October).

Five years of cash, in billions

n/a
-0.0
-0.0
-0.0
-0.0
-0.1
2021202220232024202512 monthsto Jun '26
Revenue
n/an/an/an/an/a
Operating margin
n/an/an/an/an/a
Debt to equity
n/an/an/an/an/a
Shares outstanding
0.06bn0.06bn0.08bn0.13bn0.14bn

Health checks

  • Free cash flow positive0 of 4 years
  • Accounting looks honest (Beneish)Not enough data
  • Financial strength (Piotroski)Not enough data
  • Profit backed by cash (accruals)Yes
  • DebtUnknown
  • Revenue growth, five yearsUnknown
  • Buying back its own sharesNo, 138% more shares since 2021

The quarter to June 2026

How the business did, compared with the same quarter a year earlier.

  • A loss of $18 million, compared with a loss of $12 million a year ago.
  • Over the past 12 months it spent $53 million more cash than it brought in, compared with $43 million a year earlier.
  • 20% more shares than a year ago. Each share owns a bit less of the company.
Profit by quarter
Profit by quarter
Quarter toAmount
September 2024-$13m
December 2024-$11m
March 2025-$10m
June 2025-$12m
September 2025-$12m
December 2025-$8m
March 2026-$13m
June 2026-$18m

From the company's quarterly reports to the SEC.

Dates

Next results (estimated)
n/a
Last annual report (10-K)
17 March 2026
Next quarterly (estimated, 10-Q)
5 November 2026

Who owns it

1 long-term investor we follow owns it, unchanged from 1 last quarter. 218 funds in all.

Jun '25
Dec '25
Jun '26
Largest holders overall

From 13F filings for the quarter ended 30 June 2026.

Big holders and activists

7 investors own more than 5%.

  • New Enterprise Associates 16, L.P.
    Passive investor
    at least 10.5%−1.1 pts
    (filed with 12 related holders)
    Since 5 May 2026
    What they said

    The Funds acquired the Firm Shares for investment purposes. Depending on market conditions, its continuing evaluation of the business and prospects of the Issuer and other factors, the Funds and other Reporting Persons may dispose of or acquire additional shares of the Issuer,…

    Read the filing
  • FMR LLC
    Passive investor
    at least 8.8%+2.5 pts
    (filed with 1 related holder)
    Since 30 June 2026
  • Frazier Life Sciences Public Fund, L.P.
    Passive investor
    at least 7.0%−3.6 pts
    (filed with 10 related holders)
    Since 30 September 2025
  • BlackRock, Inc.
    Passive investor
    5.6%
    Since 30 September 2025
  • Viking Global Investors
    Passive investor
    at least 4.2%−1.7 pts
    (filed with 10 related holders)
    Since 30 September 2025
  • at least 2.9%−4.2 pts
    (filed with 1 related holder)
    Since 31 December 2025
  • Venrock Healthcare Capital Partners II, L.P.
    Passive investor
    at least 1.4%
    (filed with 9 related holders)
    Since 31 December 2024
  • Rosalind Advisors, Inc.
    Passive investor
    Sold down below 5%
    Since 13 February 2025
  • The Vanguard Group
    Passive investor
    Sold down below 5%
    Since 13 March 2026

From Schedule 13D and 13G filings: anyone owning more than 5% must file one.

What insiders did

No insider bought shares on the open market in the last 12 months. 1 sold $595,806, $595,806 of it under preset trading plans.

  • Heffernan Michael Thomas
    Director
    Sold
    under a preset trading plan
    Date
    15 September 2026
    Shares
    39,473
    Price
    $15.09
    Value
    $595,806

From Form 4 filings: insiders must report trades in their own company's shares within two days.

What could go wrong

Cheap for a reason is the question the numbers cannot answer.

Whether the price already reflects the risks is what the deep dive is for.

The deep dive

Everything above is arithmetic on public filings. The deep dive reads the last ten years of annual reports, the proxy statements, and the earnings calls, then argues the case the way Buffett, Klarman, and Hohn would, and checks every claim against the source.

  • What the business is worth, as a range, and the margin of safety at today’s price
  • Prices to start buying, buy, and buy hard
  • The three things that would make this a mistake
  • Every number footnoted to the filing it came from
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What a finished deep dive looks like

Not advice. Numbers on this page come from SEC filings and are updated each night; prices are updated again after the US market closes. The five-year figures are rounded.